Matrixyl 3000

matrixyl 3000 for wrinkles

Most cosmetic companies employ their own scientists and do their own research for the compounds they are going to incorporate into the products they produce. Sometimes this research yields results that are what is considered as “game changers”. One such game changer was released in 2003 by Sederma Corporation under the name Matrixyl. Further research on this compound yielded an even more interesting compound which received the name Matrixyl 3000.

Actually the only thing the two compounds have in common is the name. Probably because Sederma wanted to leverage the success of the original compound which became a staple on most cosmetic products that are poised to address the needs of the skin. It is a usual practice for the marketing departments to distort things a bit in order to achieve higher sales. Most people do not even know the terms anyway; they only enjoy the results.

How Matrixyl 3000 Works to Reduce Wrinkle Appearance

To start understanding the meanings we need to begin by defining the meaning of a peptide.


To make things as elementary as possible, peptides are parts of proteins that result naturally when the carboxyl group of one amino acid interacts with the amino group of another. When the bond linking these groups is a single one then the peptide is called dipeptide. As the number of bonds increases, we have tripeptides, tetrapeptides, pentapeptides, etc… Grouping these names we have oligopeptides (the number of bonds is low) and polypeptides (the number of bonds is high). Each peptide performs a different function depending on the amino acids involved in its creation.


The scientific name is palmitoyl-pentapeptide 3. This peptide was discovered when the scientists were looking for ways to increase the collagen production. It is the specific substance that has the function of increasing the synthesis of collagen and repair the skin. In 2013, a study conducted at the University of Reading determined that Matrixyl can in fact almost double the production of collagen required to maintain the skin’s elasticity.

Matrixyl 3000

As they say the enemy of good is better. Sederma tried to improve on Matrixyl and came up with Matrixyl 3000. It still is a peptide, but this time it is a combination of two peptides: palmitoyl oligopeptide and palmitoyl-tetrapeptide-7. While the general idea is still the same, i.e. to produce more collagen, this time it is done in a different way. The combination actually fools the skin into believing that there is damage somewhere and therefore it needs to react to repair it. In a way it forces the skin to create more collagen on its own.

An even more interesting concept about Matrixyl 3000 is that it can perform more complicated functions than simple Matrixyl. One of the two parts of palmitoyl oligopeptide is GHK. This is derived by the three amino acids that were joined. GHK is also a part of the copper peptides that can actually remodel the skin, repair wounds, improve on the structure of the skin and reduce scars.

In effect, Matrixyl 3000 can, under one combination or another, provide the entire set of the anti-aging properties that are so fervently sought after. Reduced or non-existent wrinkles, fine lines, dark circles, puffiness, shagginess along with a level of protection against the sun, the cold, the heat, the wind and all other elements of nature and the other harmful agents that threaten the skin.

However, research has not yet determined if this can actually be the case or not. It still is a fairly new compound that must undergo thorough testing before the full set of effects it can provide for the skin become known. The same testing must also determine whether there are any side-effects after long term usage.

Adverse effects

So far none of the reviews either by dermatologists or by users have mentioned any kind of short term side-effects. However, since Matrixyl 3000 is now used in many different skincare products manufactured by many different companies, there is no way to know if the combination of ingredients that each manufacturer chooses can have any side-effect or not.

Until all clinical and other tests have been completed, it is recommended to withhold reactions that raise this compound to the status of a miracle skin healer. This is a time consuming process and until the official results come out it would be best if the use of products containing Matrixyl 3000 is given the proper care for any precautions and safety measures recommended by the various manufacturers.


Like any new discovery, Matrixyl 3000 is promising a lot. So far it seems to deliver on its promises and provide the anti-aging results that the female of the species is so desperate about. So far we can only see what Sederma says about it:

Wrinkles: reduced 15% in depth, 18% in volume, 44% in the area covered and 37% in density

Roughness: reduced by 14%

Complexity: reduced by 18%

Skin tone: increased by 15%

An interesting issue in the study released by Sederma is that there is no mention of side-effects testing or any testing for safety. There is also no reference to any effects to the eyes as the compound is used to eye creams which are applied too close to the sockets and have to be ophthalmologically tested.

The gold standard of determining if a cosmetic is first of all safe and then living up to its promises is the release of unbiased independent studies. Some of these studies are conducted now at various organizations and some others have been planned for the future. Everyone keeps their fingers crossed that Matrixyl 3000 will not be another compound that does more damage than good in the long run.

When used with other peptide ingredients, such as this anti wrinkle peptide, a very powerful, results-oriented product can be used effectively to hide and  reduce the appearance of facial wrinkles.

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